Abstract: OBJECTIVE: Serum proteomics in the screening of tumor biomarkers has been widely used. We identified specific plasma candidate tumor biomarkers of cervical squamous cell carcinoma in Uyghur women by two-dimensional differential ingel electrophoresis. METHODS：We collected plasma samples from Uyghur women with cervical lesions and prepared low abundant plasma proteins. After the establishment of a differential proteome profile by two-dimensional differential ingel electrophoresis. mass spectrometry and bioinformatics technology were used to identify and analyze the function of differential proteins. RESULTS：A differential proteome profile was established for Uyghur women with cervicitis and early stage cervical carcinoma. 16 proteins were detected among the 43 differentially expressed between two patient groups，7 were up- regulated and 9 were down- regulated. The primary pathways involved included complement and metabolism-related proteins and enzymes. CONCLUSION：In this study，by focusing on the low abundant plasma proteome biomarker in Uyghur women with high-risk of cervical cancer，we provided evidence for prevention，early diagnosis and carcinogenesis mechanism of cervical cancer in Xinjiang Uyghur women.

Key words: Uyghur women, cervical squamous cell carcinoma, plasma proteome, two-dimensional differential ingel electrophoresis, mass spectrometry